| Pop Song | Live | Recd | Maps and Legends |
| Sad Discoverer: | 1998 | Also known as Diminished | |
| Sad Lovers Waltz: (Traditional) | 1986 | ||
| Sad Professor: | 1998 | 1998 | |
| Sad Professor (Live in the Studio): | 1998 | ||
| Salt & Pepper: (Ernest Noyes Brookings) | 1989 | Live 1989: A poem read by Michael Stipe on TV | |
| Samba: | 1987 | 1986 | Known as Underneath the Bunker |
| Same Changes: (Sam Phillips /T-Bone Burnett) | 1994 | Recd 1994: Peter Buck / Sam Phillips | |
| San Francisco (Be Sure To Wear Some Flowers In Your Hair): (John Phillips) | 2001 | Live 2001: Mike Mills / The Croakers | |
| Saturday Night: (Bay City Rollers) | 1987 | Medley with Strange / Bay City Rollers Show Theme | |
| Saturday Night Church: (Barrett Martin / Justin Harwood) | 1996 | 1997 | Live 1996: Peter Buck / Tuatara Recd 1997: Peter Buck / Tuatara |
| Saturn Return: | 2001 | ||
| Save For Me: (Kevn Kinney) | 1990 | Live 1990: Peter Buck / Kevn Kinney | |
| Scarred But Smarter: (Kevn Kinney / Tim Nielsen / Paul Lenz) | 1990 | Live 1990: P. Buck / M. Mills / R. Hitchcock / K. Kinney Also live 1990: P. Buck / K. Kinney | |
| Second Guessing: | 1983 | 1983 | Also live 1984: Hindu Love Gods w/ Michael Stipe / Bryan Cook / Warren Zevon on vocals |
| Secret Agent Man: (Sloan / Barri) | 1980 | Also live 1983: It Crawled From the South | |
| Sedan Delivery: (Neil Young) | 1999 | Live 1999: Mike Mills / The Minus 5 / The Possibilities | |
| See No Evil: (Tom Verlaine) | 1984 | 1988 | |
| See That My Grave Is Kept Clean: (Folk standard / Traditional) | 1987 | Live 1987: The Mystery Twins | |
| Sentimental Hygiene: (Warren Zevon) | 1987 | Recd 1987: Bill Berry / Peter Buck / Mike Mills / Warren Zevon | |
| Serengeti: (Tuatara) | 1997 | Live 1997: Peter Buck / Tuatara | |
| Serpentine River: (Christy McWilson) | 2002 | Recd 2002: Peter Buck / Christy McWilson | |
| Set 'em Up Joe: (Fern Dolsten?) | 1990 | Live 1990: Peter Buck / Brian Burke / Nikki Sudden / Crumpy | |
| 7 Chinese Brothers: | 1983 | 1983 | |
| Sex Bomb: (Shatter / Calderwood / Falconi / Depace) | 1994 | ||
| Sex Bomb Baby: (?) | 1984 | ||
| Sexual Healing: (Marvin Gaye) | 1989 | Live 1989: Peter Buck / Ilene & Peter Holsapple | |
| Shake This Town: (Robbie Robertson) | 1991 | Recd 1991: Mike Mills / Robbie Robertson | |
| Shakin' All Over: (Johnny Kidd & the Pirates) | 1980 | Also Live 2000: Peter Buck / The Minus 5 | |
| Shake Your Love: (Debbie Gibson) | 1996 | Live 1996: Peter Buck / The Minus Five | |
| Shaking Through: | 1981 | 1981 | |
| Shame On Doing Wrong: (Richard Thompson) | 1986 | Live 1986: Michael Stipe / Goldon Palominos | |
| Sharp Dressed Man: (Frank Beard / Billy F. Gibbons / Dusty Hill) | 1985 | ||
| She Belongs To Me: (Bob Dylan) | 2000 | Live 2000: Peter Buck / The Minus 5 | |
| She Doesn't Exist: (Robyn Hitchcock) | 1991 | Recd 1991: Michael Stipe / Peter Buck / Robyn Hitchcock & the Egyptians | |
| She Justs Want To Be: | 2001 | 2001 | |
| She Knows How To Do It: (?) | 1993 | Live 1993: Michael Stipe / 10,000 Maniacs | |
| She Said, She Said: (John Lennon / Paul McCartney) | 1989 | Live 1989: Nigel & the Crosses | |
| Sheep Song: (Christy McWilson) | 2002 | Recd 2002: Peter Buck / Christy McWilson | |
| (She's a ) Brickhouse: (Brothers Four) | 1985 | ||
| She's So Untouchable: (Johnny Thunders) | 1990 | Live 1990: Peter Buck / Nikki Sudden | |
| She's Such A Pretty Girl: | 1981 | Known as Hey! Hey! Nadine | |
| Sheherazade: | 1980 | Also known as Lisa Says ? | |
| Shine: | 2001 | Unreleased demo | |
| Shiny Happy People: | 1991 | 1991 | |
| Shiny Happy People (Hip Mix): | 1991 | ||
| Shiny Happy People (Music Mix): | 1991 | ||
| Shiny Happy People (Pop Mix): | 1991 | ||
| Ship Song: (Christy McWilson) | 2000 | 2000 | Recd 2000 / Live 2000: Peter Buck / Christy McWilson |
| Shock Therapy: (Jamie Hoover) | 1984 | Recd 1984: R.E.M. / Spongetones | |
| Sidewinder Sleeps Tonite, The: | 1992 | ||
| Silver Bells: (Jay Livingston / Ray Evans) | 1993 | ||
| Simple Gifts: (Traditional) | 1987 | A cappella prelude to I Believe | |
| Sin City: (Gram Parsons / Chris Hillman) | 1989 | Live 1989: Nigel & the Crosses | |
| Sing, Sing A Song: (Fisher / Fisher) | 1998 | Sesame Street performance - first broadcast 2000 | |
| Singing Cage, The: (Traditional) | 1985 | A cappella | |
| Sitting Still: | 1981 | 1981 | |
| Sitting Still: | 1981 | 10 seconds of the song done "Polka style" included on the "Cassette Set" | |
| Six Stock Answers For 74,000 Questions: (M. Stipe / Matthew Sweet) | 1983 | Live 1983: Community Trolls | |
| Skank: | 1981 | 1983 | Demo recording, not released Also known as Marble Table and Taking Out the Seeds |
| Skin Tight: (Jones / Pierce / Bonner / Middelbrooks) | 1985 | 1989 | Live version recorded |
| Skip A Rope: (Henson Cargill) | 1985 | ||
| Slapstick Heart: (B. Berry / P. Buck / M. Mills / Sam Phillips / M. Stipe) | 1996 | Recd 1996: Sam Phillips' recording, but cowritten by R.E.M. | |
| Slippin' & Slidin': (R. Penniman / E. Bocage / J. Smith / A. Collins) | 1991 | Live 1991: R.E.M. as William with Ben Reynolds on vocals | |
| Sloop John B: (arr. Wilson) | 1984 | ||
| Slow Death: (Loney / Jordan) | 2002 | Live 2002: Peter Buck / Roy Loeny & The Longshots | |
| Slow Down: (Larry Williams) | 1993 | Recd 1993: Mike Mills / Backbeat Band (ost) | |
| Slowly Fading Evening Sky: (David Lewis) | 1995 | Recd 1995: Peter Buck / David Lewis | |
| Small Town Girl: | 1981 | Known as Hey! Hey! Nadine | |
| Smile Away: (Paul McCartney) | 2000 | Live 2000: Peter Buck / The Minus 5 | |
| Smiling Faces Sometimes: (Undisputed Truth) | 1991 | ||
| Smoke Rings: (Barrett Martin / Justin Harwood) | 1997 | Live 1997: Peter Buck / Tuatara | |
| Smokin' In The Boys' Room: (M. Roda / M. Luts) | 1984 | Vocals by Bill Berry and Mike Mills | |
| Smokestack Lightnin': (Chester Burnett) | 1984 | ||
| Smugglerős Cove: (Mike Stone / Barrett Martin / Skerik) | 1998 | 1998 | Live 1998: Peter Buck / Tuatara Recd 1998: Peter Buck / Tuatara |
| So Awake Volunteer: | 1989 | 1988 | Known as The Eleventh Untitled Song |
| So Fast So Numb: | 1995 | 1996 | Live 1995: Performed during soundcheck |
| So You Think You're In Love: (Robyn Hitchcock) | 1990 | 1991 | Also live 1991: Bingo Hand Job Recd 1991: Peter Buck / Robyn Hitchcock & the Egyptians |
| So You Want To Be A Rock 'N' Roll Star: (R. McGuinn / C. Hillman) | 1983 | Live 1983: It Crawled From the South Live 1984: R.E.M. | |
| Socio Blues: (Kevn Kinney) | 1990 | Live 1990: Peter Buck / Kevn Kinney | |
| Solitary Man: (Neil Diamond) | 1993 | Live 1993: Michael Stipe / Vic Chesnutt | |
| Soma: (William Eorgan / James Iha) | 1993 | Recd 1993: Mike Mills / Smashing Pumpkins | |
| Someday: (Christy McWilson) | 2000 | 2000 | Recd 2000 / Live 2000: Peter Buck / Christy McWilson |
| Something: (George Harrison) | 2001 | Live 2001: Mike Mills / The Croakers | |
| Sometimes I Wish I Was A Pretty Girl: (Robyn Hitchcock) | 1991 | Live 1991: Bingo Hand Job | |
| Sometimes Good Guys Don't Wear White: (Standells) | 2001 | Live 2001: Peter Buck / The Minus 5 | |
| So. Central Rain (I'm Sorry): | 1983 | 1983 | Also known as Southern Central Rain: |
| Southern Central Rain: | 1983 | 1983 | Known as So. Central Rain (I'm Sorry): |
| Spend a Little Gold With Me: (Trad. arr. Nikki Sudden) | 1990 | 1990 | Live 1990: Peter Buck / Nikki Sudden Recd 1990: Peter Buck / Nikki Sudden |
| Speed Metal: | Demo recorded in 1990 (without lyrics) | ||
| Spidery Moon: (Peter Buck / Scott McCaughey) | 1997 | Recd 1997: Peter Buck / The Minus 5 | |
| Sponge: (Vic Chesnutt) | 1995 | 1995 | Live 1995: As prelude to It's The End Of The World As We Know It |
| Spooky: (M. Middlebrooks / M. Shapiro) | 1986 | Also live 1987: The Mystery Twins | |
| S t. Catherine's Statue: (Jimmy Silva) | 1996 | Live 1996: Peter Buck / The Minus 5 | |
| Stand: | 1988 | 1988 | |
| Star Me Kitten: | 1995 | 1992 | Also recd 1996: w/ William S. Burroughs (ost) Also known as Fuck Me Kitten |
| Star 69: | 1995 | 1994 | |
| Star Spangled Banner: (John Stafford Smith / Francis Scott Key) | 1984 | Live 1984: Prelude to Little America Also live 1989 / 1996: A cappella by Mike Mills | |
| Still Somebody To Me: (Christy McWilson) | 1996 | Live 1996: Peter Buck / The Minus 5 | |
| Storm Crazy: (Peter Buck / Chris Eckman) | 1995 | Recd 1995: Peter Buck / Chris & Carla | |
| Story: (Scott McCaughey) | 1995 | 1994 | Live 1995: Peter Buck / Mike Mills / The Minus 5 Recd 1994: Peter Buck / The Minus 5 |
| Straight to Hell: (Kevn Kinney) | 1989 | Live 1989: Mike Mills / Drivin' 'n' Cryin' Also live 1989: Peter Buck / Drivin' 'n' Cryin' | |
| Stranded In The Jungle: (New York Dolls) | 1981 | Live 1981: Medley with The Lion Sleeps Tonight & Skank | |
| Strange: (B. Gilbert / G. Lewis / C. Newman / R. Gotobed) | 1985 | 1987 | |
| Strange Condition: (Peter Yorn) | 2002 | Recd 2002: Peter Buck / Peter Yorn | |
| Strange Currencies: | 1995 | 1994 | Also known as With Love Comes Strange Currencies |
| Strange Currencies (Instrumental Version): | 1994 | ||
| Strawberry Road: (Sam Phillips) | 1994 | Recd 1994: Peter Buck / Sam Phillips | |
| Streets Of New Dehli, The: (Barrett Martin / Justin Harwood) | 1998 | Recd 1998: Peter Buck / Tuatara | |
| Streets Of Your Town: (Forster / McLennan) | 1989 | ||
| Strokin': (Clarence Carter) | 1997 | Live 1997: Mike Mills / Hootie and The Blowfish | |
| Stronger Than Dirt: | 1981 | 1981 | Known as White Tornado |
| Strychnine: (Gary Roslie) | 2001 | Live 2001: Peter Buck / The Minus Tad | |
| Stuck In The Middle With You: (Steelers Wheel) | 1993 | Live 1993: Mike Mills / Robyn Hitchcock / Jules Shear Also Live 2000: Peter Buck / The Minus 5 | |
| Stumble: | 1981 | 1981 | |
| Stunned & Frozen: (Peter Buck / Mark Eitzel) | 1997 | 1996 | Live 1997: Peter Buck / Mark Eitzel Recd 1996: Peter Buck / Mark Eitzel |
| Subway Train: (Johnny Thunders / David JoHansen) | 1984 | As prelude to Jimmy Crackcorn | |
| Suede Shoe Blues: (Kevn Kinney) | 1990 | Live 1990: Peter Buck / Kevn Kinney | |
| Surfing The Ganges: | 1998 | ||
| Sugar Cane: | Demo recorded in 1990 during Out of Time sessions Known as Mandolin Strum | ||
| Summer Turns To High: | 2001 | Also known as: 32 Chord Song | |
| Summertime: (George Gershwin) | 1988 | 1990 | Live 1988: Michael Stipe / Indigo Girls Also live 1989: R.E.M. |
| Sun: (Jez Willis / Michael Stipe ) | 2000 | Recd 2000: Michael Stipe / Utah Saints | |
| Sunday Morning: (Lou Reed / John Cale) | 1987 | Live 1987: The Mystery Twins as a part of a medley | |
| Sunshine Of Your Love: (Jack Bruce / Pete Brown / Eric Clapton) | 1984 | Live 1984: w/ Peter Holsapple as a medley with Freddie's Dead | |
| Sunshine On My Shoulders: (John Denver) | 1987 | Live 1987: The Mystery Twins as a part of a medley | |
| Sun Is Shining, The: (Jimmy Reed / Trad.arr. Nikki Sudden) | 1990 | 1990 | Live 1990 / Recd 1990: Buck / Sudden Rewritten by Sudden as Spend a Little Gold With Me |
| Superior: (Chickasaw Mudd Puppies) | 1991 | Recd 1991: Michael Stipe / Chickasaw Mudd Puppies | |
| Superman: (Gary Zekley / M. Bottler) | 1986 | 1986 | Also live 1986: w/ Gary Zekley Also live 1986: Berry / Mills / Corn Cob Webs First cover song on record / First vocals by Mike Mills |
| Suspicion: | 1998 | 1998 | |
| Suspicious: (Reg Presley) | 1992 | Recd 1992: Bill Berry / Peter Buck / Mike Mills / The Troggs | |
| Suspicious Minds: (Mark James) | 1984 | Live 1984: w/ Peter Holsapple Also Live 1999: Prelude to Man On The Moon | |
| Swamp: | 1996 | Known as Low Desert | |
| Swan Swan H: | 1985 | 1986 | Also live 1991: Bingo Hand Job Also known as 3/4 |
| Sweet Caroline: (Neil Diamond) | 1995 | ||
| Sweet Emotions: (Aerosmith) | 1985 | Live 1985: Michael Stipe / Mike Mills / The Neats | |
| Sweet Home Alabama: (Gary Rossington / Ed King / Ronnie Van Zandt) | 1984 | Also live 1984: Peter Buck / Adolf and the Casuals Vocals by Mike Mills | |
| Sweet Jane: (Lou Reed) | 1983 | ||
| Sweetness Follows: | 1999 | 1992 | |
| Swiftly, But Gently: (Kurt Bloch) | 2001 | Live 2001: Peter Buck / The Minus Tad | |
| Swing Low Sweet Chariot: (Traditional) | 1984 | A cappella | |
| Swirling: (Robyn Hitchcock) | 1989 | 1989 | Live 1989: Nigel & the Crosses Recd 1989: Peter Buck / R. Hitchcock & the Egyptians |
| Swirly Song, The: | 1987 | 1987 | Known as Fireplace |
| Syllables: (Kevn Kinney) | 1991 | Live 1991: Peter Buck / Drivin' 'n' Cryin' | |
| Sympathy For The Devil: (Mick Jagger / Keith Richard) | 1985 | Live 1985: Peter Buck / Green on Red Also live 1995: R.E.M. used the lyrics during Java |